| Characteristic | Detail |
|---|---|
| Active Ingredient | Sildenafil Citrate |
| Available Dosages | 20 mg |
| Administration Route | Oral |
| Mechanism of Action | PDE5 Inhibitor |
| Storage Conditions | Below 30°C (86°F) |
| Learn More | |
Pharmacokinetics
The pharmacokinetics of Revatio 20 mg describe its absorption, distribution, metabolism, and excretion. Upon oral administration, it is absorbed rapidly. Bioavailability stands at approximately 41%. The systemic distribution reveals an extensive volume of distribution, around 105 liters. Metabolism occurs primarily in the liver, involving the cytochrome P450 enzymes, particularly CYP3A4 and CYP2C9. The half-life is about four hours.
Renal excretion accounts for minimal clearance, with most of the compound eliminated as metabolites in feces. When taken with food, the absorption rate slows, reducing the peak concentration but not the extent of absorption. These pharmacokinetic properties ensure a targeted duration of action, optimizing its therapeutic effect.
Areas of Use
Revatio, with its active ingredient sildenafil, finds utility primarily in the treatment of pulmonary arterial hypertension (PAH). It improves exercise capacity in adults by relaxing blood vessels in the lungs, decreasing resistance, and alleviating pressure. This effect enhances oxygenation during physical exertion.
In clinical settings, it serves as an adjunct for managing specific cases of heart disease. This role underscores its critical place in therapeutic regimens for cardiovascular conditions. Health practitioners administer it with care, adhering to prescribed guidelines for optimized outcomes.
Who Can and Cannot Take Revatio
Revatio 20 mg is recommended for adult patients diagnosed with pulmonary arterial hypertension. However, its suitability must be evaluated by a healthcare provider, considering individual health parameters. Patients with severe liver or renal impairment, recent stroke or myocardial infarction, or hypotension should avoid it.
Those taking nitrates in any form should not consume sildenafil 20 mg, as this combination poses significant risks of severe hypotension. Pediatric populations and pregnant or breastfeeding women should only take Revatio under strict medical supervision.
Revatio Storage
Store Revatio below 30°C (86°F) in its original packaging to shield it from moisture and heat. The medicine should remain out of reach of children, ensuring safety. Avoid storing it in bathrooms or areas with high humidity.
Proper storage is vital to maintain its efficacy. Follow these guidelines strictly to preserve the pharmacological integrity of the compound.
Effects of Revatio
Sildenafil 20 mg induces vasodilation in pulmonary arteries. This action reduces pulmonary vascular resistance and pressure. It enhances exercise capacity, translating into improved quality of life for patients. Some experience mild headaches, flushing, or dizziness. These effects usually diminish as the body adjusts.
Adverse reactions, while uncommon, include visual disturbances and hearing loss. Immediate medical attention is required if such symptoms manifest. Regular follow-up is essential to monitor the patient’s response and adjust treatment as necessary.
Revatio Over The Counter
Revatio 20 mg is not available over the counter. It requires a prescription due to its specific indications and potential for side effects. The prescription ensures that use aligns with diagnosed conditions, and prevents misuse.
Prescription also facilitates monitoring by healthcare providers, allowing timely interventions if adverse reactions occur. Buying Revatio without proper medical guidance could lead to significant health risks, emphasizing the importance of regulated distribution.
| Factor | Impact |
|---|---|
| Food Interaction | Delays Absorption |
| Half-life | 4 Hours |
- Prescription Required
- Store Below 30°C
- Avoid Nitrates
- Regular Monitoring
For more scientific details on Revatio and its application, visit NCBI PubMed.
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